At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

About the Role:

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• Design and execute experiments to discover and validate targets, lead project groups, and work with internal/external collaborators to advance projects in Neuroimmunology

• As part of a multifunctional team, develop and validate cell systems for evaluating new drugs targeting neuroglial/Neuro-immune cell interactions and identify novel pathways for drug discovery

• Use pharmacological and genetic tools to modulate new targets and understand their biology in primary cells including immune cells and cellular models of neurologic and immune diseases, iPSCs (ALS, Parkinson's, Alzheimer's, etc) and immune cells from autoimmune patients

• Understand and Conduct in vivo experimental work (functional testing, IV/PO/IP administration, and tissue collection) using animal models including autoimmune disease model and brain disorders to support new target discovery projects and understand cellular physiology

• Key contributor to and a resource for the Neuroimmunology and Neurodegeneration project teams and work effectively and cross-functionally with internal and external collaborators to projects

• Interact in a matrixed, dynamic, and cross-functional manner across the Neuroscience Therapeutic Area, Research Platforms, and other groups

• Effectively interacts with multiple functions across the organization and effectively communicates results and strategies to staff and company executives

• Establish and lead external relationships with CROs to drive method technology transfer, batch release, and ongoing stability studies

• Other duties as assigned

• PhD degree in Immunology, Neuroimmunology, Neurosciences and/or related science discipline and relevant experience; may include postdoc experience OR

• MS/MA degree in Biological Sciences preferably related to Immunology, Neuroimmunology, Neuroscience, or Pharmacology and 8+ years of similar experience above OR

• BS/BA degree in Biology, Life Sciences or related discipline preferably related to immunology and neuroscience and 10+ years of experience in the biotech/pharmaceutical industry with exposure to drug discovery

• Research experience with myeloid cell, microglia and cell interaction is preferred.

• Experience with scRNAseq, CITE-RNAseq is a plus.

• Demonstrated expertise and scientific achievement in both autoimmune and CNS diseases and/or other related fields.

• Expert level in rodent neurodegenerative disease models and autoimmune disease models

• Expertise in culture of stable transfection for cell line, isolation, and culture of human or mouse blood cells and tissue derived primary cells such as macrophages, splenocytes, microglia, neurons, and astrocytes

• Expertise in CRISPR technology, siRNA, flow analyzers, cell phenotyping analysis, signaling pathways in immune cells, glial, and neuronal cells

• Expertise in core molecular biology techniques and biochemistry is essential (DNA, RNA, and protein extraction, Western-blot, ELISA, MSD, multiplex bead arrays, PCR, RNAseq, etc.)

• Demonstrated expertise with in vivo studies in rodents with CRO management are a plus

• Proven success managing internal/external lab personnel

• Strong attention to detail, excellent written and oral communication skills

• Proactive, innovative, with good problem-solving skills

• Ability to work in a cross functional team and matrix environment

• Ability to influence others with or without authority at all levels of the organization

• Excellent written, presentation, and verbal communication skills

• Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools

• Sees broader picture, impact on multiple programs, teams and/or departments

• Demonstrates solid level of understanding project / group goals and methods

• Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes

• Able to explain the process behind the data and implications of the results

• Strong knowledge of one or more scientific disciplines, becoming expert in one discipline

• Strong knowledge of scientific principles, methods and techniques

• Strong knowledge and demonstrated ability working with a variety of laboratory equipment/tools

• Ability to work as part of a team; may train lower levels.

• Ability to leading teams

• Excellent computer skills

• Strong communications, problem-solving, analytical thinking skills

• Detail oriented yet can see broader picture of scientific impact on team

• Ability to meet multiple deadlines, with a high degree of accuracy and efficiency

• Strong project management skills

• Must have working knowledge of Microsoft Office, Word, and Excel

• Advanced multitasking, trouble shooting and deductive reasoning skills required

• Demonstrate strong publication in peer reviewed scientific journals

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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