Postdoctoral Research on Epigenetics of tRNA
Postdoctoral positions are available in the lab of Dr. Ya-Ming Hou at Thomas Jefferson University, Sidney Kimmel Medical College. We study epigenetic post-transcriptional modifications of tRNA and how they impact codon-specific translation in diseases. Codon-specific translation is a new mechanism that regulates gene expression at the codon level and it is activated or repressed by stress. Current projects are:
- Codon-specific translation in response to stress.
- Epigenetics of tRNA in neurodegenerate diseases.
For more information, please see the following publications and our website:
Nucleic Acids Res. 45, 4081-4093 (2017). PMID: 27956502
PNAS 113, 15096-15101 (2016). PMID: 27849575 (Featured in PNAS commentary)
Nat Struct Mol Biol, 10, 941-948 (2016). PMID: 27571175. (Featured in Science)
Nature Communications, 6:7226 (2015). PMID: 26009254
Chem and Biol (Cell Press) 21, 1351-1360 (2014). PMID: 25219964
Nature 510, 507-511 (2014). PMID: 24919148 (Featured in Nature News and Views)
Nat. Communications. 2:329 (2011). PMID: 21629262
Candidates with an expected or recent Ph.D. and a strong research track record are encouraged to apply. Experience in RNA-seq, high-throughput data analysis, fluorescence microscopy, cell culture, molecular biology, protein enzymology, nucleic acid research, and mitochondrial research is preferred.
Please send a cover letter, CV, and names and contact information of three references to:
Professor of Biochemistry and Mol Biology
Thomas Jefferson University
233 S. 10th Street, BLSB 220
Philadelphia, PA 19107, USA