Research Associate - Comparative Molecular Biology
The Research Associate will perform research of an advanced nature under the general direction of the Principal Investigator, requiring skilled knowledge of fundamental techniques and practices related to genetics, genomics and molecular biology. The Aiden lab's work is cutting edge and lies on the intersection of biology, computer science, physics and mathematics and its primary focus is exploring the three-dimensional structure of the human genome. The lab's work has been featured on the cover of Nature, Science and Cell. Dr. Aiden and his team have been responsible for seminal advances in a diverse array of fields spanning molecular biology, polymer physics, mathematics, and others. These include the invention of three dimensional genome sequencing, and consequent discoveries of the mechanisms of genome compartmentalization (Lieberman-Aiden et al., Science, 2009; Lieberman Aiden, Science, 2011) and loop extrusion (Sanborn & Rao et al., PNAS, 2015); the first reliable, genome-wide maps of chromatin looping (Rao & Huntley et al., Cell, 2014, Rao et al., Cell, 2017); and the development of 3D genome surgery to modify genome folding using targeted mutations (Sanborn & Rao et al., PNAS, 2015).
- Design, prepare and conducts functional genomics experiments such as Hi-C, RNA-Seq, ChIP- Seq, ATAC-Seq
- Maintain, manipulate and occasionally establish mammalian cell lines (experience in mammalian cell culture is essential, experience with iPSC culturing and transformation as well as establishing primary fibroblast culture is preferred)
- Maintain a large biological specimens repository, ensure long-term integrity and preservation of collection, which include genetic material and linked ancillary digital metadata, improve collection and storage protocols
- Organize and prepare documentation necessary for specimen accession, including national and international permits and associated documentation
- Respond to specimen requests, data inquiries, specimen photo requests etc
- Participate in data analysis
- Supervise and coordinate the activities of less experienced research staff and occasionally assist with grant writing
- Participate in overseeing day-to-day laboratory operation and maintaining security protocols and standards
- Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
- Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.
- Experience in basic fundamental molecular biology techniques (such as gel electrophoresis, Western blotting, PCR, qPCR, etc.)
- Experience in mammalian cell culture and aseptic techniques
- Experience with maintenance and establishment of primary fibroblast cell cultures, iPSC culturing and transformation strongly preferred
- Experience in one or more of the following is strongly preferred: next generation sequencing library preparation; functional genomics (RNA-Seq, ChIP-Seq, ATAC-Seq)
- Data analytic skills
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
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