At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

About the Role:

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• Responsibilities include generating and screening site-directed, CDR randomization and combinatorial antibody libraries for affinity maturation and developability optimization

• Critical member of the team contributing to characterizing antibodies and antibody-based therapeutics (for e.g. affinity, specificity, cross-species binding, epitope determination)

• Will be involved in the engineering of advanced modalities such as bispecific antibodies

• Contribute to the design and cloning of antigens

• Responsible for understanding data from multiple sources including experimental, structural models, informatics and literature/patents, forming hypotheses, devising strategy

• Contribute to the evaluation of emerging molecular biological or biochemical methods, initiate and support new platforms, instrumentation and technologies for antibody engineering

• Working with protein biochemists, cell biologists and gene therapists to achieve goals

• Other duties as assigned

• BS/BA degree in Molecular Biology, Biochemistry or other relevant discipline and 4+ years of relevant experience OR

• MS/MA degree in Molecular Biology, Biochemistry or other relevant discipline and 3+ years of relevant experience OR

• PharmD or PhD in Molecular Biology, Biochemistry or other relevant discipline and some relevant experience; may include postdoc experience

• MAbs/bi specifics - understanding of antibody protein structure & function, ability to apply protein engineering principles to mAb drug design. Practical experience with affinity determination methods, and execution of antibody optimization campaigns using directed evolution screening platforms. Knowledge of immunogenicity assays, and state-of-the-art antibody technologies

• Hands-on experience in the design and execution of antibody optimization campaigns using directed evolution screening platforms such as capture-lift, automated/high throughput or yeast display

• and software, oligo design coupled with strong desire to work in the laboratory

• Comfort analyzing antibodies structurally in standard software packages such as Pymol or MOE

• Experience with standard laboratory instrumentation: PCR, centrifugation, DNA quantitation, gel documentation systems, plate readers and washers, liquid handling, etc.

• Familiarity with affinity determination methods (e.g. ELISA, MSD, Octet, Carterra, Biacore or Kinexa)

• History of maintaining detailed experimental documentation, entering data into LIMS/Benchling

• Familiarity with various antibody formats including Fab, scFv, IgG, nanobody and multispecific derivatives a plus

• Excellent communication and interpersonal skills

• Proficiency in Microsoft Office and DNA sequence analysis software such as Sequencher, Geneious or SnapGene

• Strong communications, problem-solving, analytical thinking skills

• Detail oriented yet can see broader picture of scientific impact on team

• Ability to meet multiple deadlines, with a high degree of accuracy and efficiency

• Strong project management skills

• Demonstrated mastery of standard molecular biology bench skills, DNA sequence analysis

#LI-DM1

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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