Position Title: Postdoctoral Associate, Peptide Chemistry

About Us:
Calibr, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Calibr's drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.

Position Summary:

We are seeking a talented Postdoctoral Associate to join our Peptide Chemistry team in San Diego. The ideal candidate will possess exceptional academic credentials in peptide chemistry, as well as expertise in bioconjugation and knowledge in chemical biology.

In this role, the successful applicant will be a key member within the laboratory and make significant contributions to the advancement of Calibr's peptide drug discovery portfolio. Primarily, the candidate will be responsible for the design and synthesis of analogs intended to enhance the potency, pharmacokinetics, safety, and in vivo efficacy of potential drug candidates.

Furthermore, the candidate will enjoy ample opportunities to learn and actively participate in multidisciplinary drug discovery projects, making a meaningful impact and engaging in independent ideation to drive innovative practices. Ultimately, this role will play a crucial part in accelerating peptide drug discovery endeavors at Calibr.

The position presents an exciting and fulfilling prospect for career growth, as it involves pioneering work in the exploration of peptide therapeutics, paving the way for the medicines of the future.

Responsibilities:

• Design, synthesize and characterize peptides and proteins using chemical synthesis, bioconjugation, purification, and biophysical experiments
• Conduct structure-activity relationship (SAR) and stability studies, with the aim of progressing molecules to IND-enabling activities
• Communicate data and reports on project status at individual, group, and departmental meetings
• Review literature and patents to retrieve key scientific information needed for research projects
• Collaborate with cross-functional teams and to drive shared objectives
• Build and enhance internal and external professional relationships
• Details of established essential functions for this position will be addressed/discussed during the interview process

Qualifications:

• Ph.D. in organic chemistry, or related field
• Skilled in contemporary peptide synthesis techniques, cyclization strategies, bioconjugation, purification methodologies, and the analytical characterization of peptide and protein conjugates.
• Hands-on familiarity with peptide structures and relevant biophysical techniques to analyze solubility, stability, and solution dynamics.
• Adept at successfully adhering to numerous deadlines across various projects, showcasing a heightened level of efficiency.
• Proven track record of impactful scientific involvement, having authored or co-authored research publications in leading, distinguished scientific journals.
• Collaborate seamlessly and convey information proficiently to both colleagues and the management team.
• Experience in molecular modeling including docking is a plus.
• Ability to excel in a fast-paced as a motivated, enthusiastic, proactive, detail-oriented, and organized individual.

Physical Requirements:

This position works in a laboratory environment. May include: Stationary position for an extended period of time, traverse campus/facility as needed,
operate machinery such as computer, phone, copy machine; exposure to cold or hot temperatures.

Compensation:

Postdoctoral Associates will be hired following the National Institute of Health and California's exempt salary guidelines, which provide for a starting range of $68,000 - $70,000. Consideration will be given to experience that exceeds the listed requirements.

Comprehensive Benefits Include:

• Eligibility for retirement plans with employer contribution.
• Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.
• Access to Flexible Spending Accounts (Medical/Dependent Care).
• Competitive vacation and sick leave policies.
• Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members.
• Free, on-site parking.

The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff.

EEO Statement:
The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status. Underrepresented individuals are encouraged to apply.